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lüll The renal urodilatin system: clinical implications Forssmann W; Meyer M; Forssmann KCardiovasc Res 2001[Aug]; 51 (3): 450-62A renal natriuretic peptide and the 'renal urodilatin system' were identified after the observation that immunoassayable ANP in urine may not be identical to the circulating cardiac hormone ANP, which is a peptide of 28 amino acids. Urodilatin (INN: Ularitide) is a natriuretic peptide isolated from human urine and belongs to the family of A-type natriuretic peptides. Urodilatin is differentially processed to a peptide of 32 amino acids from the same precursor as ANP. It is synthesized in kidney tubular cells and secreted luminally. After secretion from epithelial cells of the distal and/or connecting tubules, Urodilatin interacts downstream at distal segments of the nephron with luminally located receptors whereby it regulates Na(+) and water reabsorption. Thus, the physiological function of the renal Urodilatin system can be described as a paracrine intrarenal regulator for Na(+) and water homeostasis, considering Urodilatin as a real diuretic-natriuretic regulatory peptide. However, the regulation upon which the Urodilatin secretion depends is still not clear. Since Urodilatin has been discovered, a great number of pharmacological and clinical investigations have been carried out using Urodilatin as a drug for several indications. So far, clinical phase I and II studies for acute renal failure, congestive heart failure, and bronchial asthma have been performed.|Animals[MESH]|Asthma/drug therapy[MESH]|Atrial Natriuretic Factor/genetics/pharmacology/*physiology[MESH]|Bronchodilator Agents/therapeutic use[MESH]|Diuresis/drug effects/*physiology[MESH]|Diuretics/therapeutic use[MESH]|Heart Failure/drug therapy[MESH]|Humans[MESH]|Peptide Fragments/genetics/pharmacology/*physiology[MESH] |