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Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis Fajas L; Debril MB; Auwerx JJ Mol Endocrinol 2001[Aug]; 27 (1): 1-9Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR-gamma, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization. Furthermore, PPAR-gamma has been reported to affect cell proliferation/differentiation pathways in various malignancies. We discuss in the present review recent advances in the understanding of the function of PPAR-gamma in both cell proliferation and adipocyte differentiation.|*Cell Transformation, Neoplastic[MESH]|Adipose Tissue/*cytology[MESH]|Animals[MESH]|Cell Differentiation/physiology[MESH]|Cell Division/physiology[MESH]|Humans[MESH]|Receptors, Cytoplasmic and Nuclear/*physiology[MESH]|Transcription Factors/*physiology[MESH] |
