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Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of anti-inflammatory therapies Geng JGCell Res 2001[Jun]; 11 (2): 85-8Directional migration of leukocytes is indispensable to innate immunity for host defense. However, recruitment of leukocytes to a site of tissue injury also constitutes a leading cause for inflammatory responses. Mechanistically, it involves a cascade of cellular events precisely regulated by temporal and spatial presentation of a repertoire of molecules in the migrating leukocytes and their surroundings (microenvironments). Here I will summarize the emerging evidence that has shed lights on the underlying molecular mechanism for directional migration of leukocytes, which has guided the therapeutical development for innovative anti-inflammatory medicines.|Animals[MESH]|Anti-Inflammatory Agents/*pharmacology/therapeutic use[MESH]|Cell Movement/drug effects/*physiology[MESH]|Heparin/pharmacology/therapeutic use[MESH]|Humans[MESH]|Inflammation/drug therapy/*immunology/physiopathology[MESH]|Leukocyte Migration-Inhibitory Factors/antagonists & inhibitors/immunology[MESH]|Leukocytes/cytology/*immunology/metabolism[MESH]|NF-kappa B/antagonists & inhibitors/immunology[MESH] |
