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Control of chromatin accessibility for V(D)J recombination by interleukin-7 Huang J; Muegge KJ Leukoc Biol 2001[Jun]; 69 (6): 907-11IL-7 is a key factor for lymphoid development, and it contributes to V(D)J recombination at multiple loci in immune-receptor genes. IL-7 signal transduction, involving gamma(c) and Jak3, is required for successful recombination at the TCR-gamma locus. IL-7 signaling controls the initiation phase of V(D)J recombination by controlling access of the V(D)J recombinase to the locus. In the absence of IL-7, the TCR-gamma locus is methylated and packaged in a repressed form of chromatin consisting of hypoacetylated histones. IL-7 signaling likely increases the acetylation state of the nucleosomal core histones resulting in an "open" form of chromatin. This opening leads to a higher accessibility for the transcription machinery and increased accessibility of the Rag heterodimer that performs the cleavage of DNA.|Acetylation[MESH]|Chromatin/*genetics/ultrastructure[MESH]|DNA Methylation[MESH]|DNA Nucleotidyltransferases/*metabolism[MESH]|DNA-Binding Proteins/physiology[MESH]|Evolution, Molecular[MESH]|Gene Expression Regulation, Developmental/*physiology[MESH]|Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor/drug effects/*physiology[MESH]|Histones/metabolism[MESH]|Homeodomain Proteins/physiology[MESH]|Humans[MESH]|Interleukin-7/*physiology[MESH]|Lymphocytes/cytology[MESH]|Lymphoid Tissue/cytology[MESH]|Nuclear Proteins[MESH]|Protein Binding[MESH]|Protein Processing, Post-Translational[MESH]|Recombination, Genetic/*physiology[MESH]|Retroelements/genetics[MESH]|Signal Transduction/drug effects/physiology[MESH]|VDJ Recombinases[MESH] |
