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lüll AP-1 in mouse development and tumorigenesis Jochum W; Passegue E; Wagner EFOncogene 2001[Apr]; 20 (19): 2401-12Genetically modified mice have provided important insights into the biological functions of the dimeric transcription factor complex AP-1. Extensive analyses of mice and cells with genetically modified Fos or Jun proteins provide novel insights into the physiological functions of AP-1 proteins. Using knock-out strategies it was found that some components, such as c-Fos, FosB and JunD are dispensable, whereas others, like c-Jun, JunB and Fra-1 are essential in embryonic development and/or in the adult organism. Besides the specific roles of AP-1 proteins in developmental processes, we are beginning to obtain a better molecular understanding of the cell-context dependent function of AP-1 in cell proliferation and apoptosis, in bone biology as well as in multistep tumorigenesis.|Animals[MESH]|Apoptosis[MESH]|Cell Division[MESH]|Mice, Knockout[MESH]|Mice, Transgenic[MESH]|Mice/*embryology[MESH]|Models, Biological[MESH]|Neoplasms/*etiology[MESH]|Osteoblasts/physiology[MESH]|Osteoclasts/physiology[MESH]|Proto-Oncogene Proteins c-fos/genetics/physiology[MESH]|Proto-Oncogene Proteins c-jun/genetics/physiology[MESH]|Transcription Factor AP-1/genetics/*physiology[MESH] |