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lüll Jun, the oncoprotein Vogt PKOncogene 2001[Apr]; 20 (19): 2365-77Cellular Jun (c-Jun) and viral Jun (v-Jun) can induce oncogenic transformation. For this activity, c-Jun requires an upstream signal, delivered by the Jun N-terminal kinase (JNK). v-Jun does not interact with JNK; it is autonomous and constitutively active. v-Jun and c-Jun address overlapping but not identical sets of genes. Whether all genes essential for transformation reside within the overlap of the v-Jun and c-Jun target spectra remains to be determined. The search for transformation-relevant targets of Jun is moving into a new stage with the application of DNA microarrays technology. Genetic screens and functional tests remain a necessity for the identification of genes that control the oncogenic phenotype.|*Cell Transformation, Neoplastic[MESH]|Animals[MESH]|Consensus Sequence[MESH]|DNA-Binding Proteins/genetics[MESH]|Dimerization[MESH]|G-Box Binding Factors[MESH]|Gene Expression Profiling[MESH]|Mutation[MESH]|Oncogene Protein p65(gag-jun)/genetics/*physiology[MESH]|Proto-Oncogene Proteins c-jun/genetics/*physiology[MESH]|Transcription Factor AP-1/genetics/physiology[MESH]|Transcription Factors/genetics[MESH]|Transcriptional Activation[MESH] |