Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
New tricks for old dogs: nonthrombotic effects of thrombin in vessel wall biology Patterson C; Stouffer GA; Madamanchi N; Runge MSCirc Res 2001[May]; 88 (10): 987-97Thrombin is a serine protease that potently activates platelets and catalyzes the conversion of fibrinogen to fibrin. Thrombin also exerts direct effects on vascular cells, such as smooth muscle cells, via interactions with members of the protease-activated receptor family. Evidence in several animal models implicates thrombin-mediated signaling events in the response to injury that typifies vascular lesion formation in atherosclerosis and restenosis. In this review, we examine the activation of protease-activated receptors by thrombin, the downstream signaling events mediated by these receptors, and the physiological role of thrombin in vascular cells and vascular disease.|Animals[MESH]|Apoptosis[MESH]|Blood Vessels/drug effects/*metabolism[MESH]|Cell Division/drug effects[MESH]|Cell Movement/drug effects[MESH]|Endothelium, Vascular/drug effects/physiology[MESH]|Enzyme Activation/physiology[MESH]|Humans[MESH]|Muscle, Smooth, Vascular/drug effects/*metabolism[MESH]|Neovascularization, Physiologic/drug effects[MESH]|Plasminogen Activator Inhibitor 1/metabolism[MESH]|Receptor, PAR-1[MESH]|Receptors, Thrombin/metabolism[MESH]|Signal Transduction/drug effects/physiology[MESH]|Thrombin/antagonists & inhibitors/*metabolism/pharmacology[MESH] |
