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Fibrin D-dimer and coronary heart disease: prospective study and meta-analysis Danesh J; Whincup P; Walker M; Lennon L; Thomson A; Appleby P; Rumley A; Lowe GDCirculation 2001[May]; 103 (19): 2323-7BACKGROUND: It is unknown whether modest increases of fibrin D-dimer, a circulating marker of fibrin turnover, are relevant to coronary heart disease (CHD) in the general population. METHODS AND RESULTS: We measured serum concentrations of D-dimer antigen in the stored baseline blood samples of 630 CHD cases and 1269 controls "nested" in a prospective cohort of 5661 men who were monitored for 16 years, and we conducted a meta-analysis of previous relevant studies to place our findings in context. In a comparison of men in the top third compared with those in the bottom third of baseline fibrin D-dimer values (tertile cutoffs, >94 versus <49 ng/mL), the odds ratio for CHD was 1.67 (95% CI, 1.31 to 2.13; P<0.0001) after adjustments for age and town. The odds ratio increased slightly after further adjustment for smoking, other classic risk factors, and indicators of socioeconomic status (1.79; 95% CI, 1.36 to 2.36). Strong correlations were observed of fibrin D-dimer values with circulating concentrations of C-reactive protein and serum amyloid A protein but not with smoking, blood lipids, blood pressure, and other risk factors. CONCLUSION: Although there may be an association between circulating D-dimer values and CHD, further studies are needed to determine the extent to which this is causal.|Adult[MESH]|Biomarkers/blood[MESH]|Case-Control Studies[MESH]|Coronary Disease/*blood/pathology[MESH]|Fibrin Fibrinogen Degradation Products/*metabolism[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Odds Ratio[MESH]|Prospective Studies[MESH]|Risk Factors[MESH] |
