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Role of ETS family transcription factors in vascular development and angiogenesis Sato YCell Struct Funct 2001[Feb]; 26 (1): 19-24The ETS family of transcription factors is defined by a conserved DNA-binding ETS domain that forms a winged helix-turn-helix structural motif. This family of transcription factors is involved in a diverse array of biological functions including cellular growth and differentiation, as well as organ development. Among the members of this family, ETS-1, ERG, Fli-1, TEL, and NERF-2 are expressed in endothelial cells and their progenitors. This review will summarize the role of ETS family transcription factors in vascular development and angiogenesis.|Animals[MESH]|Endothelium, Vascular/growth & development/*physiology[MESH]|Humans[MESH]|Multigene Family/physiology[MESH]|Neovascularization, Physiologic/*physiology[MESH]|Proto-Oncogene Protein c-ets-1[MESH]|Proto-Oncogene Proteins c-ets[MESH]|Proto-Oncogene Proteins/*physiology[MESH]|Transcription Factors/*physiology[MESH] |
