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Bopindolol: pharmacological basis and clinical implications Nagatomo T; Hosohata Y; Ohnuki T; Nakamura T; Hattori K; Suzuki J; Ishiguro MCardiovasc Drug Rev 2001[Spr]; 19 (1): 9-24Bopindolol, a non-selective antagonist of beta 1- and beta 2-adrenoceptors (ARs), has been found by pharmacological, molecular biological techniques and molecular modeling to have several unique properties. Bopindolol produces sustained blockade of beta 1- and beta 2-ARs, has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Also, our recent molecular modeling studies identified possible interaction sites between bopindolol and beta-AR subtypes. The reviewed studies support our findings that bopindolol is non-selective for beta 1- and beta 2-ARs, has low affinity for beta 3-AR subtype and has pharmacological properties that are likely to be beneficial in the treatment of cardiovascular diseases.|Adrenergic beta-Antagonists/chemistry/*pharmacokinetics/therapeutic use[MESH]|Animals[MESH]|Cardiovascular Diseases/*drug therapy[MESH]|Disease Models, Animal[MESH]|Hemodynamics/drug effects[MESH]|Models, Molecular[MESH]|Myocardial Contraction/drug effects[MESH]|Pindolol/analogs & derivatives/chemistry/*pharmacokinetics/therapeutic use[MESH]|Receptors, Adrenergic, beta/chemistry/drug effects/metabolism[MESH]|Receptors, Serotonin/drug effects/metabolism[MESH]|Renin/antagonists & inhibitors/metabolism[MESH] |
