Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
RNA and DNA aptamers as potential tools to prevent cell adhesion in disease Ulrich H; Alves MJ; Colli WBraz J Med Biol Res 2001[Mar]; 34 (3): 295-300Recent research has shown that receptor-ligand interactions between surfaces of communicating cells are necessary prerequisites for cell proliferation, cell differentiation and immune defense. Cell-adhesion events have also been proposed for pathological conditions such as cancer growth, metastasis, and host-cell invasion by parasites such as Trypanosoma cruzi. RNA and DNA aptamers (aptus = Latin, fit) that have been selected from combinatorial nucleic acid libraries are capable of binding to cell-adhesion receptors leading to a halt in cellular processes induced by outside signals as a consequence of blockage of receptor-ligand interactions. We outline here a novel approach using RNA aptamers that bind to T. cruzi receptors and interrupt host-cell invasion in analogy to existing procedures of blocking selectin adhesion and function in vitro and in vivo.|Animals[MESH]|Cell Adhesion[MESH]|Cell Adhesion Molecules/*physiology[MESH]|Cell Communication[MESH]|Chagas Disease/parasitology[MESH]|DNA/chemistry/*metabolism[MESH]|Host-Parasite Interactions[MESH]|Humans[MESH]|Integrins/metabolism[MESH]|L-Selectin/analysis[MESH]|P-Selectin/analysis[MESH]|Protozoan Proteins/chemistry/metabolism[MESH]|RNA-Binding Proteins/*metabolism[MESH]|RNA/chemistry/*metabolism[MESH]|Trypanosoma cruzi/*metabolism[MESH] |
