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lüll Molecular motors involved in T cell receptor clusterings Krawczyk C; Penninger JMJ Leukoc Biol 2001[Mar]; 69 (3): 317-30Engagement of antigen receptors on T and B cells triggers reorganization of the cytoskeleton and ordered clustering of cell surface receptors. These receptor clusters constitute spatially organized signaling machines and form the immune synapse with antigen-presenting cells. Formation of supramolecular activation clusters appear to be essential to induce functional lymphocyte responses and have been implicated as molecular mechanisms of costimulation. The Vav1-Rho-GTPase-WASP pathway constitutes a molecular motor that relays antigen receptor stimulation to changes in the cytoskeleton and receptor clustering.|Animals[MESH]|Antigen-Presenting Cells/immunology/metabolism/physiology[MESH]|B-Lymphocytes/immunology/metabolism/physiology[MESH]|Humans[MESH]|Lymphocyte Activation/immunology/physiology[MESH]|Molecular Motor Proteins/immunology/metabolism/*physiology[MESH]|Receptors, Antigen, T-Cell/immunology/metabolism/*physiology[MESH]|T-Lymphocytes/immunology/metabolism/physiology[MESH] |