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lüll Intracellular surveillance: controlling the assembly of MHC class I-peptide complexes Cresswell PTraffic 2000[Apr]; 1 (4): 301-5MHC class I molecules bind with high affinity to peptides in the endoplasmic reticulum and display them on the cell surface. Here they are screened by CD8-positive T-lymphocytes for the presence of foreign, pathogen-derived peptides within the mass of self-peptides expressed. MHC class I assembly is a complicated process involving a number of accessory molecules, including specialized components as well as common chaperones. Our understanding of the mechanisms involved, while quite advanced, is far from complete.|Animals[MESH]|CD8-Positive T-Lymphocytes/metabolism[MESH]|Endoplasmic Reticulum/metabolism[MESH]|Histocompatibility Antigens Class I/*chemistry/*metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|Molecular Chaperones/metabolism[MESH]|Peptides/*chemistry/metabolism[MESH]|Protein Transport[MESH] |