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The reverse transcriptase model of somatic hypermutation Steele EJ; Blanden RVPhilos Trans R Soc Lond B Biol Sci 2001[Jan]; 356 (1405): 61-6The evidence supporting the reverse transcriptase model of somatic hypermutation is critically reviewed. The model provides a coherent explanation for many apparently unrelated findings. We also show that the somatic hypermutation pattern in the human BCL-6 gene can be interpreted in terms of the reverse transcriptase model and the notion of feedback of somatically mutated sequences to the germline over evolutionary time.|*Mutation[MESH]|Animals[MESH]|DNA-Binding Proteins/genetics[MESH]|Humans[MESH]|Immunoglobulin Variable Region/*genetics[MESH]|Models, Genetic[MESH]|Proto-Oncogene Proteins c-bcl-6[MESH]|Proto-Oncogene Proteins/genetics[MESH]|RNA-Directed DNA Polymerase/*physiology[MESH]|Recombination, Genetic[MESH]|Transcription Factors/genetics[MESH] |
