Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Somatic hypermutation of immunoglobulin and non-immunoglobulin genes Storb U; Shen HM; Michael N; Kim NPhilos Trans R Soc Lond B Biol Sci 2001[Jan]; 356 (1405): 13-9Somatic hypermutation (SHM) of immunoglobulin (Ig) genes is a highly specific mechanism restricted to B lymphocytes during only a few cell generations. Data presented here suggest that transcription of the target genes is required, but not sufficient for SHM. Presumably, cis-acting elements, such as those present in the Ig enhancers, are required to target a mutator factor (MuF) to Ig and human BCL-6 genes. It is postulated that the MuF travels with the transcribing RNA polymerase and is deposited on the target gene when the polymerase pauses. Point mutations, and rare deletions and insertions, are created by the combined actions of MuF and certain DNA polymerases. A subset of the mutations is corrected during SHM by DNA mismatch repair.|*Mutation[MESH]|Animals[MESH]|B-Lymphocytes/*physiology[MESH]|DNA Repair/genetics[MESH]|DNA-Binding Proteins/*genetics[MESH]|Humans[MESH]|Immunoglobulins/*genetics[MESH]|Mice[MESH]|Models, Genetic[MESH]|Proto-Oncogene Proteins c-bcl-6[MESH]|Proto-Oncogene Proteins/*genetics[MESH]|Transcription Factors/*genetics[MESH]|Transcription, Genetic[MESH] |