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l�ll Crawling and wiggling on DNA: structural insights to the mechanism of DNA unwinding by helicases Marians KJStructure 2000[Dec]; 8 (12): R227-35Crystal structures have recently been solved of the monomeric DNA helicase PcrA bound to forked DNA, and of the hexameric helicase domain of the bacteriophage T7 gene 4 protein, a replication fork DNA helicase/primase. These structures have led to the elaboration of the first molecular models to describe DNA helicase action.|Bacterial Proteins/chemistry/metabolism[MESH]|Computer Simulation[MESH]|DNA Helicases/*chemistry/*metabolism[MESH]|DNA Primase/chemistry/metabolism[MESH]|DNA, Bacterial/*chemistry/*metabolism[MESH]|Models, Molecular[MESH]|Structure-Activity Relationship[MESH] |