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An overview of the potassium channel family Miller CGenome Biol 2000[]; 1 (4): REVIEWS0004Potassium channels, tetrameric integral membrane proteins that form aqueous pores through which K+ can flow, are found in virtually all organisms; the genomes of humans, Drosophila, and Caenorhabditis elegans contain 30-100 K+ channel genes each. The structure of a bacterial K+ channel, sequence comparisons with other channels and electrophysiological measurements have enabled conclusions about the mechanism of gating and ion flow to be drawn for many other channels.|*Evolution, Molecular[MESH]|Animals[MESH]|Humans[MESH]|Ion Channel Gating[MESH]|Models, Molecular[MESH]|Potassium Channels/*chemistry/genetics/metabolism[MESH]|Protein Conformation[MESH] |
