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lüll The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma Brouwer R; Pruijn GJ; van Venrooij WJArthritis Res 2001[]; 3 (2): 102-6The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75. These autoantigens have been reported to associate into a large complex consisting of 11 to 16 proteins and to play a role in ribosome synthesis. Recently, it was discovered that the PM/Scl complex is the human counterpart of the yeast (Saccharomyces cerevisiae) exosome, which is an RNA-processing complex consisting of 11 3' --> 5' exoribonucleases. To date, 10 human exosome components have been identified, although only some of these were studied in more detail. In this review, we discuss some recent advances in the characterization of the PM/Scl complex.|Autoantigens/chemistry/*immunology[MESH]|Exoribonucleases/chemistry/*immunology[MESH]|Exosome Multienzyme Ribonuclease Complex[MESH]|Humans[MESH]|Multienzyme Complexes/chemistry/*immunology[MESH]|Polymyositis/*enzymology/*immunology[MESH]|Scleroderma, Systemic/*enzymology/*immunology[MESH] |