Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Ets factors and regulation of the extracellular matrix Trojanowska MOncogene 2000[Dec]; 19 (55): 6464-71Ets factors are critical mediators of extracellular matrix (ECM) remodelling. As the spectrum of Ets-regulated target genes widens, so does their role in various pathological and physiological processes. Regulation of matrix degrading proteases by Ets factors in tumor invasion and metastasis is well established. Emerging evidence suggests that they may also play a role in the pathology of autoimmune diseases. Newly characterized Ets target genes such as tenascin-C and collagen type I suggest their role in diseases characterized by aberrant collagen deposition (fibrosis). Ets function is also critical in bone and cartilage development. There is increasing knowledge of the complex regulatory mechanisms involved in transcription of Ets target genes. Ets factors may function as activators or as repressors via association with specific cofactors depending on the promoter context. Signaling pathways can modulate the activation status of Ets factors and their transcriptional partners. Precise understanding of the role of Ets factors in the complex cellular network governing the expression of ECM proteins and the enzymes that degrade them will be a focus of future studies.|*DNA-Binding Proteins[MESH]|*Multigene Family[MESH]|*Repressor Proteins[MESH]|3T3 Cells[MESH]|Animals[MESH]|Autoimmune Diseases/metabolism[MESH]|Bone and Bones/embryology/metabolism[MESH]|Cartilage/embryology[MESH]|Chick Embryo[MESH]|Collagen/metabolism[MESH]|Enzyme Induction/genetics[MESH]|Extracellular Matrix Proteins/metabolism[MESH]|Extracellular Matrix/*metabolism[MESH]|Gene Expression[MESH]|Humans[MESH]|Metalloendopeptidases/genetics/metabolism[MESH]|Mice[MESH]|Neoplasm Invasiveness[MESH]|Neoplasm Metastasis[MESH]|Neoplasm Proteins/genetics/physiology[MESH]|Neovascularization, Pathologic/genetics/metabolism[MESH]|Oncogene Proteins/genetics/physiology[MESH]|Osteogenesis/genetics[MESH]|Phenotype[MESH]|Proto-Oncogene Protein c-ets-2[MESH]|Proto-Oncogene Proteins c-ets[MESH]|Proto-Oncogene Proteins c-jun/physiology[MESH]|Proto-Oncogene Proteins/genetics/metabolism/physiology[MESH]|Signal Transduction/genetics[MESH]|Sp1 Transcription Factor[MESH]|Tenascin/metabolism[MESH]|Trans-Activators/genetics/metabolism[MESH]|Transcription Factors/genetics/*physiology[MESH]|Transcriptional Regulator ERG[MESH]|Tumor Cells, Cultured[MESH]|Wound Healing/genetics[MESH] |
