Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Stimulation of arteriogenesis; a new concept for the treatment of arterial occlusive disease van Royen N; Piek JJ; Buschmann I; Hoefer I; Voskuil M; Schaper WCardiovasc Res 2001[Feb]; 49 (3): 543-53After birth two forms of vessel growth can be observed; angiogenesis and arteriogenesis. Angiogenesis refers to the formation of capillary networks. Arteriogenesis refers to the growth of preexistent collateral arterioles leading to formation of large conductance arteries that are well capable to compensate for the loss of function of occluded arteries. The process of arteriogenesis is initiated when shear stresses increase in the preexistent collateral pathways upon narrowing of a main artery. The increased shear stress leads to an upregulation of cell adhesion molecules for circulating monocytes, which accumulate subsequently around the proliferating arteries and provide the several required cytokines and growth factors. Several strategies are currently tested for their potential to stimulate the process of arteriogenesis. These strategies focus either at shear stress, at direct stimulation of endothelial and smooth muscle cell growth or at the monocytic pathway and promising results were obtained from experimental studies. However, some important questions remain to be answered before arteriogenesis can be brought from bench to bedside.|*Collateral Circulation[MESH]|*Neovascularization, Physiologic[MESH]|Animals[MESH]|Arterial Occlusive Diseases/*therapy[MESH]|Blood Vessels/embryology[MESH]|Chemokines/genetics/metabolism[MESH]|Disease Models, Animal[MESH]|Dogs[MESH]|Exercise Therapy[MESH]|Gene Expression[MESH]|Growth Substances/*therapeutic use[MESH]|Monocytes/physiology[MESH]|Morphogenesis[MESH]|Research Design[MESH]|Stress, Mechanical[MESH]|Swine[MESH] |