Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Interdomain interactions in oligomeric enzymes: creation of asymmetry in homo-oligomers and role in metabolite channeling between active centers of hetero-oligomers Nagradova NKFEBS Lett 2001[Jan]; 487 (3): 327-32Interdomain interactions play an important role in the structural organization of many enzymes and the conformational flexibility of their molecules. In this review, the role of intrasubunit and intersubunit domain-domain interactions in the origins of pre-existent asymmetry of homo-oligomeric D-glyceraldehyde-3-phosphate dehydrogenase and tryptophanyl-tRNA synthetase is discussed on the basis of recent X-ray data and other available information about the properties of these and related enzymes. In addition, a novel key function of interdomain interactions is considered: their potential contribution to intramolecular channeling of intermediates between active centers located on different subunits of a hetero-oligomeric enzyme (alpha,beta-heterodimeric carbamoyl phosphate synthetase).|Animals[MESH]|Binding Sites[MESH]|Carbamoyl-Phosphate Synthase (Ammonia)/chemistry/metabolism[MESH]|Enzymes/*chemistry/*metabolism[MESH]|Escherichia coli/enzymology[MESH]|Geobacillus stearothermophilus/enzymology[MESH]|Glyceraldehyde-3-Phosphate Dehydrogenases/chemistry/metabolism[MESH]|In Vitro Techniques[MESH]|Models, Molecular[MESH]|Protein Structure, Quaternary[MESH]|Protein Structure, Tertiary[MESH]|Rabbits[MESH]|Tryptophan-tRNA Ligase/chemistry/metabolism[MESH]|Tyrosine-tRNA Ligase/chemistry/metabolism[MESH] |