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lüll Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2 Delany NS; Hurle M; Facer P; Alnadaf T; Plumpton C; Kinghorn I; See CG; Costigan M; Anand P; Woolf CJ; Crowther D; Sanseau P; Tate SNPhysiol Genomics 2001[Jan]; 4 (3): 165-74Remarkable progress has been made recently in identifying a new gene family related to the capsaicin (vanilloid) receptor, VR1. Using a combination of in silico analysis of expressed sequence tag (EST) databases and conventional molecular cloning, we have isolated a novel vanilloid-like receptor, which we call VRL-2, from human kidney. The translated gene shares 46% and 43% identity with VR1 and VRL-1, respectively, and maps to chromosome 12q23-24.1, a locus associated with bipolar affective disorder. VRL-2 mRNA was most strongly expressed in the trachea, kidney, and salivary gland. An affinity-purified antibody against a peptide incorporating the COOH terminal of the receptor localized VRL-2 immunolabel in the distal tubules of the kidney, the epithelial linings of both trachea and lung airways, serous cells of submucosal glands, and mononuclear cells. Unlike VR1 and VRL-1, VRL-2 was not detected in cell bodies of dorsal root ganglia (DRG) or sensory nerve fibers. However, VRL-2 was found on sympathetic and parasympathetic nerve fibers, such as those innervating the arrector pili smooth muscle in skin, sweat glands, intestine, and blood vessels. At least four vanilloid receptor-like genes exist, the newest member, VRL-2 is found in airway and kidney epithelia and in the autonomic nervous system.|*Cation Transport Proteins[MESH]|*Ion Channels[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Blotting, Northern[MESH]|Cell Line[MESH]|Chromosome Mapping[MESH]|Chromosomes, Human, Pair 12/genetics[MESH]|Cloning, Molecular[MESH]|DNA, Complementary/chemistry/genetics/isolation & purification[MESH]|Female[MESH]|Humans[MESH]|Immunohistochemistry[MESH]|In Situ Hybridization, Fluorescence[MESH]|Male[MESH]|Molecular Sequence Data[MESH]|RNA/genetics/metabolism[MESH]|Radiation Hybrid Mapping[MESH]|Rats[MESH]|Receptors, Drug/*genetics/metabolism[MESH]|Sequence Alignment[MESH]|Sequence Analysis, DNA[MESH]|Sequence Homology, Amino Acid[MESH]|TRPV Cation Channels[MESH]|Tissue Distribution[MESH] |