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lüll BRCA1 and cell signaling Wang Q; Zhang H; Fishel R; Greene MIOncogene 2000[Dec]; 19 (53): 6152-8The breast cancer and ovarian cancer susceptibility gene BRCA1 encodes a nucleoprotein whose mutations or aberrant expression is associated with both inherited and sporadic cancers. Studies over the last 6 years have suggested that BRCA1 may function as a scaffold in the assembly of a multi-protein complex, which plays a role in gene transcription, DNA damage repair, and transcription-coupled DNA damage repair. In this review, we discuss the implications drawn from the studies of BRCA1-interacting proteins and the cellular signaling pathways that may be involved in controlling the functions of BRCA1.|*Signal Transduction[MESH]|Animals[MESH]|Apoptosis[MESH]|BRCA1 Protein/*physiology[MESH]|Cell Cycle[MESH]|Chromosome Segregation[MESH]|DNA Damage[MESH]|DNA Repair[MESH]|Gene Expression Regulation[MESH]|Humans[MESH] |