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Wnt signaling: an embarrassment of receptors Bejsovec ACurr Biol 2000[Dec]; 10 (24): R919-22Recent genetic studies in Drosophila and mouse have uncovered a new aspect of the Wnt signal transduction machinery. Mutations disrupting LDL-receptor related proteins produce loss-of-function Wnt phenotypes, suggesting that these cell surface molecules may represent essential co-receptors for Wnt ligands.|*Drosophila Proteins[MESH]|*Zebrafish Proteins[MESH]|Animals[MESH]|Frizzled Receptors[MESH]|Membrane Glycoproteins/metabolism[MESH]|Membrane Proteins/metabolism[MESH]|Mitogens/genetics/metabolism[MESH]|Models, Biological[MESH]|Morphogenesis/*genetics[MESH]|Proteoglycans/metabolism[MESH]|Proto-Oncogene Proteins/genetics/*metabolism[MESH]|Receptors, G-Protein-Coupled[MESH]|Receptors, LDL/genetics/*metabolism[MESH]|Signal Transduction/*physiology[MESH]|Wnt Proteins[MESH] |
