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Glucagon-like peptide-1: a major regulator of pancreatic beta-cell function Perfetti R; Merkel PEur J Endocrinol 2000[Dec]; 143 (6): 717-25Glucagon-like peptide-1 (GLP-1) is a gut hormone synthesized by post-translational processing in intestinal L-cells, and it is released in response to food ingestion. GLP-1 stimulates insulin secretion during hyperglycemia, suppresses glucagon secretion, stimulates (pro)-insulin biosynthesis and decreases the rate of gastric emptying and acid secretion. GLP-1 has also been shown to have a pro-satiety effect. In addition, it has been demonstrated that a long-term infusion with GLP-1, or exendin-4, a long-acting analog of human GLP-1, increases beta-cell mass in rats. In conclusion, GLP-1 appears to regulate plasma glucose levels via various and independent mechanisms. GLP-1 is an excellent candidate option for the treatment of patients with type 2 diabetes mellitus.|Animals[MESH]|Gene Expression Regulation/physiology[MESH]|Glucagon/metabolism[MESH]|Humans[MESH]|Hyperglycemia/physiopathology[MESH]|Insulin Secretion[MESH]|Insulin-Like Growth Factor I/genetics/*physiology[MESH]|Insulin/metabolism[MESH]|Islets of Langerhans/*physiology/physiopathology[MESH] |
