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Neurological potassium channelopathies Benatar MQJM 2000[Dec]; 93 (12): 787-97Potassium channel dysfunction has been implicated in a variety of genetic and acquired neurological disorders that are collectively referred to as the potassium channelopathies. These include acquired neuromyotonia, episodic ataxia type-1, hereditary deafness syndromes, benign familial neonatal convulsions and hypokalaemic periodic paralysis. Insight into potassium channel structure and function is crucial to understanding the pathophysiology of these conditions. This article describes potassium channel structure and function and then outlines what is known about the immunology and genetics of the neurological potassium channelopathies.|Epilepsy, Benign Neonatal/physiopathology[MESH]|Humans[MESH]|Isaacs Syndrome/physiopathology[MESH]|Nervous System Diseases/*physiopathology[MESH]|Potassium Channels/chemistry/*physiology[MESH]|Spinocerebellar Degenerations/physiopathology[MESH] |
