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Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs Steinmeyer JArthritis Res 2000[]; 2 (5): 379-85Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to the most frequently used drugs. The discovery of an inducible isoform of cyclo-oxygenase (COX-2) has led to an intensive worldwide search and the introduction of selective COX-2 inhibitors. In this review, recent advances in understanding the mechanism of action of NSAIDs and, in this context, clinical findings on NSAID-induced gastrointestinal side effects are summarized. This knowledge is important for the effective treatment of pain and inflammation, as well as for preventing serious and sometimes lethal gastrointestinal side effects.|Animals[MESH]|Anti-Inflammatory Agents, Non-Steroidal/*adverse effects[MESH]|Cyclooxygenase Inhibitors/pharmacology[MESH]|Humans[MESH]|Inflammation/drug therapy/physiopathology[MESH]|Pain/*drug therapy[MESH] |
