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lüll Choosing a first-line drug in the management of elevated blood pressure: what is the evidence? 2: Beta-blockers Wright JMCMAJ 2000[Jul]; 163 (2): 188-92Elevated blood pressure is associated with an increased risk of cardiovascular illness and death. Efforts to reduce that risk have led to recommendations for a wide array of nondrug and drug therapies. Choosing the optimal first-line drug for hypertensive patients should address a hierarchy of treatment goals: decrease in morbidity and mortality associated with hypertension, decrease in blood pressure, good tolerance, dosing convenience and low cost. This article examines the evidence for beta-blockers as a class of first-line antihypertensive drugs in light of these treatment goals. The evidence indicates that beta-blockers are probably not as effective in reducing morbidity and mortality as low-dose thiazide diuretics and that there may be significant differences in effectiveness among various beta-blockers.|*Benzothiadiazines[MESH]|Adrenergic beta-Antagonists/adverse effects/economics/*therapeutic use[MESH]|Blood Pressure/*drug effects[MESH]|Decision Making[MESH]|Diuretics[MESH]|Humans[MESH]|Hypertension/*drug therapy/physiopathology[MESH]|Incidence[MESH]|Randomized Controlled Trials as Topic[MESH]|Sodium Chloride Symporter Inhibitors/adverse effects/economics/*therapeutic use[MESH]|Survival Rate[MESH]|Treatment Outcome[MESH] |