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A clinicopathological classification of granulomatous disorders James DGPostgrad Med J 2000[Aug]; 76 (898): 457-65Granulomatous disorders comprise a large family sharing the histological denominator of granuloma formation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity. There is a complex interplay between invading organism or prolonged antigenaemia, macrophage activity, a Th1 cell response, B cell overactivity and a vast array of biological mediators. Differential diagnosis and management demand a skilful interpretation of clinical findings and pathological evidence. They are classified into infections, vasculitis, immunological aberration, leucocyte oxidase deficiency, hypersensitivity, chemicals, and neoplasia.|B-Lymphocytes/immunology[MESH]|Diagnosis, Differential[MESH]|Granuloma/*classification/diagnosis/etiology[MESH]|Humans[MESH]|Macrophages/immunology[MESH]|Th1 Cells/immunology[MESH] |
