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lüll Chronic systemic capillary leak syndrome Report of a case and review of the literature Airaghi L; Montori D; Santambrogio L; Miadonna A; Tedeschi AJ Intern Med 2000[Jun]; 247 (6): 731-5Systemic capillary leak syndrome (SCLS) is a rare condition characterized by recurrent episodes of generalized oedema and severe hypotension, associated with paraproteinaemia. In addition to the acute form, a few cases of chronic SCLS have been reported. We describe a 64-year-old woman who was hospitalized because of a 6-month history of progressive generalized oedema with pericardial and pleural effusions, associated with a serum paraprotein. Clinical and laboratory findings were consistent with a chronic form of SCLS. Treatment with prednisone, furosemide and theophylline was started, which led to a gradual improvement in 2 weeks and a persistent remission after 9 months. This report indicates that SCLS may occur in a chronic form, which seems to be responsive to a therapeutic regimen with prednisone, furosemide, and theophylline.|Capillary Leak Syndrome/complications/*diagnosis/*drug therapy[MESH]|Chronic Disease[MESH]|Diagnosis, Differential[MESH]|Diuretics/therapeutic use[MESH]|Edema/etiology[MESH]|Female[MESH]|Furosemide/therapeutic use[MESH]|Glucocorticoids/therapeutic use[MESH]|Humans[MESH]|Middle Aged[MESH]|Paraproteinemias/etiology[MESH]|Pericardial Effusion/etiology[MESH]|Pleural Effusion/etiology[MESH]|Prednisone/therapeutic use[MESH]|Theophylline/therapeutic use[MESH]|Vasodilator Agents/therapeutic use[MESH] |