Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Functions of semaphorins in axon guidance and neuronal regeneration Goshima Y; Sasaki Y; Nakayama T; Ito T; Kimura TJpn J Pharmacol 2000[Apr]; 82 (4): 273-9The semaphorin family comprises secreted and transmembrane signaling proteins that function in the nervous, immune, respiratory and cardiovascular systems. Sema3A, a secreted type of semaphorin, is now recognized as the most potent repulsive molecule inhibiting or repelling neurite outgrowth. The biological actions of Sema3A are mediated via neuropilin (Npn)-1, a receptor or one of the components of a receptor complex for Sema3A. Although the molecular mechanisms of Sema3A-Npn-1 signaling are largely unknown, a pertussis toxin-sensitive trimeric G protein(s), Rac-1, collapsin response mediator protein (CRMP), cyclic nucleotides and tyrosine kinase(s) have been implicated as essential and/or modulatory components of these processes. As repulsive molecules could be impediments to axon outgrowth, determining how these repulsive molecules exert their actions has the potential of uncovering new therapeutic approaches to injury and/or degeneration of neuronal tissues.|*Semaphorins[MESH]|Animals[MESH]|Axons/*physiology[MESH]|Cell Adhesion Molecules, Neuronal/physiology[MESH]|Humans[MESH]|Intercellular Signaling Peptides and Proteins[MESH]|Nerve Growth Factors/*physiology[MESH]|Nerve Regeneration/*physiology[MESH]|Nerve Tissue Proteins/*physiology[MESH]|Neuropilin-1[MESH]|Semaphorin-3A[MESH] |
