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  lüll Primarily chronic and cerebrovascular course of Lyme neuroborreliosis: case  reports and literature review Wilke M; Eiffert H; Christen HJ; Hanefeld FArch Dis Child  2000[Jul]; 83 (1): 67-71As part of an ongoing study aiming to define the clinical spectrum of  neuroborreliosis in childhood, we have identified four patients with unusual  clinical manifestations. Two patients suffered from a primarily chronic form of  neuroborreliosis and displayed only non-specific symptoms. An 11 year old boy  presented with long standing symptoms of severe weight loss and chronic headache,  while the other patient had pre-existing mental and motor retardation and  developed seizures and failure to thrive. Two further children who presented with  acute hemiparesis as a result of cerebral ischaemic infarction had a  cerebrovascular course of neuroborreliosis. One was a 15 year old girl; the  other, a 5 year old boy, is to our knowledge the youngest patient described with  this course of illness. Following adequate antibiotic treatment, all patients  showed substantial improvement of their respective symptoms. Laboratory and  magnetic resonance imaging findings as well as clinical course are discussed and  the relevant literature is reviewed.|Adolescent[MESH]|Cerebral Infarction/etiology[MESH]|Cerebrovascular Disorders/diagnosis/*etiology[MESH]|Child[MESH]|Child, Preschool[MESH]|Chronic Disease[MESH]|Failure to Thrive/etiology[MESH]|Female[MESH]|Headache/etiology[MESH]|Humans[MESH]|Immunologic Tests[MESH]|Lyme Neuroborreliosis/*complications/diagnosis[MESH]|Magnetic Resonance Imaging[MESH]|Male[MESH]|Paresis/etiology[MESH]|Seizures/etiology[MESH]|Weight Loss[MESH] |