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lüll Evaluation of the thyroid nodule McCaffrey TVCancer Control 2000[May]; 7 (3): 223-8BACKGROUND: Clinically detectable thyroid nodules occur in up to 4% of the population in the United States. With ultrasound, nodules may be found in up to 50% of those over 50 years of age. METHODS: The author reviews his own experience as well as that of others to define a sound clinical approach to the differential diagnosis and detection of thyroid cancer. RESULTS: Prior neck irradiation is a risk factor for thyroid malignancy. The association of a thyroid nodule with enlarged lymph nodes or fixation of the nodule to strap muscles or the trachea suggests malignancy. A diffusely multinodular gland is usually benign. CONCLUSIONS: Thyroid function tests rarely help a differential diagnosis. Fine-needle aspiration is the "gold standard" for diagnosis. Tiny "incidentalomas" are often followed with repeat monitoring for change of size or character.|Biopsy, Needle[MESH]|Diagnosis, Differential[MESH]|Humans[MESH]|Physical Examination[MESH]|Risk Factors[MESH]|Thyroid Function Tests[MESH]|Thyroid Neoplasms/*diagnosis/pathology[MESH]|Thyroid Nodule/*diagnosis/pathology[MESH] |