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Targeted toxins Frankel AE; Kreitman RJ; Sausville EAClin Cancer Res 2000[Feb]; 6 (2): 326-34Targeted toxins, consisting of tumor-selective ligands coupled to polypeptide toxins, represent a new class of cancer therapeutics that kills malignant cells by inactivating cytosolic protein synthesis and inducing apoptosis. A number of these molecules have been produced under good manufacturing practice conditions and given systemically to patients with a variety of neoplasms. The promising results to date and the remaining pharmacological hurdles are discussed.|Antineoplastic Agents/adverse effects/*therapeutic use[MESH]|Cytotoxins/adverse effects/*therapeutic use[MESH]|Drug Design[MESH]|Humans[MESH]|Immunotoxins/adverse effects/*therapeutic use[MESH]|Neoplasms/*drug therapy[MESH] |
