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Molecular control of nitric oxide synthases in the cardiovascular system Papapetropoulos A; Rudic RD; Sessa WCCardiovasc Res 1999[Aug]; 43 (3): 509-20Nitric oxide plays an important role in cardiovascular homeostasis. In this review, the regulation of the three nitric oxide synthase isoforms in the cardiovascular system are examined at molecular and cellular levels. In addition, recent information gleaned from the use of NOS knockout mice are discussed.|*Gene Expression Regulation[MESH]|Animals[MESH]|Blood Pressure[MESH]|Cardiovascular Diseases/enzymology[MESH]|Cardiovascular System/*metabolism[MESH]|Central Nervous System/enzymology[MESH]|Homeostasis[MESH]|Humans[MESH]|Immune System/enzymology[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Neovascularization, Pathologic[MESH]|Nitric Oxide Synthase Type I[MESH]|Nitric Oxide Synthase Type II[MESH]|Nitric Oxide Synthase Type III[MESH]|Nitric Oxide Synthase/*genetics[MESH]|Nitric Oxide/*metabolism[MESH]|Rats[MESH]|Vasomotor System/enzymology[MESH] |