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lüll Ticlopidine-induced aplastic anemia: development of chromosomal abnormalities and response to immunosuppressive therapy Pullarkat VA; Rho H; Murata-Collins JL; Liebman HAAm J Hematol 2000[Mar]; 63 (3): 141-4Severe aplastic anemia is a well-recognized complication of ticlopidine therapy that carries a high mortality. Therapy with colony-stimulating factors or corticosteroids has been largely ineffective in this disorder. We report a case of ticlopidine-induced aplastic anemia that was successfully treated with cyclosporine and high-dose dexamethasone. The patient rapidly responded to immunosuppressive therapy and had a normal hemogram after cessation of immunosuppression. On long-term follow-up, the patient developed a progressive macrocytic anemia. Repeat bone marrow evaluation demonstrated myelodysplasia with erythroid hypoplasia. An associated chromosomal abnormality consisting of a t(3;16) (q21; p13.3) translocation was detected. This is the first report of a chromosomal abnormality associated with ticlopidine induced marrow aplastic anemia.|Aged[MESH]|Aged, 80 and over[MESH]|Anemia, Aplastic/*chemically induced/*drug therapy/genetics[MESH]|Bone Marrow/*drug effects[MESH]|Chromosome Aberrations/*chemically induced/*drug therapy[MESH]|Chromosome Disorders[MESH]|Cyclosporine/therapeutic use[MESH]|Dexamethasone/therapeutic use[MESH]|Fibrinolytic Agents/adverse effects[MESH]|Humans[MESH]|Immunosuppressive Agents/*therapeutic use[MESH]|Male[MESH]|Platelet Aggregation Inhibitors/adverse effects[MESH]|Ticlopidine/*adverse effects[MESH]|Treatment Outcome[MESH] |