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Acanthamoeba keratitis: a review Claerhout I; Kestelyn PBull Soc Belge Ophtalmol 1999[]; 274 (ä): 71-82Acanthamoeba keratitis is caused by protozoa and characterised by a protracted course. All patients presenting with a therapy-resistant keratitis, even non-contact lens wearers, should be examined for the presence of Acanthamoeba by means of specific cultures, histopathological stainings and--if necessary--a corneal biopsy. The combination of clinical signs, such as excessive pain, a radial keratoneuritis and in a later phase a stromal ring infiltrate, together with a suggestive history (contact lenses, polluted water) is an important factor for the early diagnosis. Because of improved clinical detection and earlier diagnosis, the infection can often be controlled with a combination therapy of polyhexamethylene biguanide or chlorhexidine with propamidine and neomycine. This results in a better visual prognosis and a decreased need for therapeutic keratoplasty.|Acanthamoeba Keratitis/*diagnosis/epidemiology/etiology/*therapy[MESH]|Contact Lenses/adverse effects[MESH]|Humans[MESH]|Risk Factors[MESH] |
