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English Wikipedia
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The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases Cane DE; Walsh CTChem Biol 1999[Dec]; 6 (12): R319-25Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) catalyze chain elongation from simple building blocks to create a diverse array of natural products. PKS and NRPS proteins share striking architectural and organizational similarities that can be exploited to generate entirely new natural products.|Catalytic Domain[MESH]|Multienzyme Complexes/*chemistry/metabolism[MESH]|Peptide Chain Initiation, Translational[MESH]|Peptide Chain Termination, Translational[MESH]|Peptide Synthases/*chemistry/metabolism[MESH]|Protein Conformation[MESH]|Ribosomes[MESH] |
