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lüll Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF Ito YGenes Cells 1999[Dec]; 4 (12): 685-96The Runt domain transcription factor PEBP2/CBF is a heterodimer of alpha and beta subunits. Of the three mammalian alpha subunit genes, which are homologues of the Drosophila gene runt, PEBP2alphaA/CBFA1 and PEBP2alphaB/AML1 are critical regulators of osteogenesis and haematopoiesis, respectively. A unique functional interaction between PEBP2alphaB/AML1 and Ets-1 was recently observed, and provides a clear example of context-dependent transcriptional regulation. An elaborate mechanism of cooperation between the two factors may represent a basis for tissue-specific gene expression, which is thought to be achieved by combinations of specific sets of transcription factors unique to each cell lineage or stage of differentiation. A possible molecular basis for the critical role(s) played by PEBP2/CBF in tissue determination is discussed in light of these observations.|*Gene Expression Regulation[MESH]|*Transcription, Genetic[MESH]|Animals[MESH]|DNA-Binding Proteins/*genetics/*metabolism[MESH]|Drosophila Proteins[MESH]|Drosophila/genetics[MESH]|Humans[MESH]|Mammals[MESH]|Transcription Factor AP-2[MESH]|Transcription Factors/*genetics/*metabolism[MESH] |