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The transporter associated with antigen processing TAP: structure and function Lankat-Buttgereit B; Tampe RFEBS Lett 1999[Dec]; 464 (3): 108-12The transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum (ER) is an essential process for presentation to cytotoxic T-lymphocytes. The transporter associated with antigen processing (TAP) is responsible for the intracellular translocation of peptides across the membrane of the ER. Efficient assembly of MHC-peptide complex requires the formation of a macromolecular transport and chaperone complex composed of TAP, tapasin and MHC class I molecules. Therefore, structure and function of TAP is important for the understanding of the immune surveillance.|Antigens/*metabolism[MESH]|Carrier Proteins/*chemistry/genetics/*metabolism[MESH]|Disease[MESH]|Endoplasmic Reticulum/metabolism[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Structure-Activity Relationship[MESH]|Substrate Specificity[MESH] |
