Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Basic mechanisms of gabitril (tiagabine) and future potential developments Meldrum BS; Chapman AGEpilepsia 1999[]; 40 Suppl 9 (ä): S2-6Gabitril (tiagabine) is a potent selective inhibitor of the principal neuronal gamma-aminobutyric acid (GABA) transporter (GAT-1) in the cortex and hippocampus. By slowing the reuptake of synaptically-released GABA, it prolongs inhibitory postsynaptic potentials. In animal models of epilepsy, tiagabine is particularly effective against kindled (limbic) seizures and against reflexly-induced generalized convulsive seizures. These data are predictive of its efficacy in complex partial seizures in humans. Possible clinical applications outside the field of epilepsy include bipolar disorder and pain.|*Membrane Transport Proteins[MESH]|*Organic Anion Transporters[MESH]|Animals[MESH]|Anticonvulsants/*pharmacology/therapeutic use[MESH]|Bipolar Disorder/drug therapy[MESH]|Carrier Proteins/drug effects[MESH]|Epilepsy/*drug therapy/metabolism/physiopathology[MESH]|GABA Antagonists/pharmacology/therapeutic use[MESH]|GABA Plasma Membrane Transport Proteins[MESH]|Humans[MESH]|Kindling, Neurologic/drug effects/physiology[MESH]|Limbic System/drug effects/physiology[MESH]|Membrane Proteins/drug effects[MESH]|Mice[MESH]|Nipecotic Acids/*pharmacology/therapeutic use[MESH]|Pain/drug therapy[MESH]|Rats[MESH]|Tiagabine[MESH]|gamma-Aminobutyric Acid/metabolism[MESH] |