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lüll Lung surfactant proteins (SP-A and SP-D) in non-adaptive host responses to infection Holmskov UJ Leukoc Biol 1999[Nov]; 66 (5): 747-52The lung surfactant proteins A and D (SP-A and SP-D) are collectins composed of C-type lectin domains attached to collagen regions. SP-A and SP-D are mainly found in the surfactant covering the pulmonary epithelial cells, but are also produced by cells lining the gastrointestinal tract. The main role of SP-A and SP-D is to interact directly with carbohydrate on the surface of microbial pathogens, thereby initiating a variety of effector mechanisms. This review focuses on the non-adaptive host responses of SP-A and SP-D to infection. Interaction of SP-A and SP-D with phagocytes is discussed and the structure and function of the putative receptors for SP-A and SP-D is presented. SP-A and SP-D seem to be regulated in a way similar to acute-phase proteins in the course of inflammation and evidence for the involvement of SP-A and SP-D as immunomodulators as well as their role in clearing allergens and modulating effector mechanisms in allergic reactions is discussed.|*Hyaluronan Receptors[MESH]|*Membrane Glycoproteins[MESH]|Adaptation, Physiological/immunology[MESH]|Animals[MESH]|Carrier Proteins[MESH]|Glycoproteins/*immunology[MESH]|Humans[MESH]|Hypersensitivity/immunology[MESH]|Infections/*immunology[MESH]|Lung/*immunology[MESH]|Mitochondrial Proteins[MESH]|Proteolipids/*immunology[MESH]|Pulmonary Surfactant-Associated Protein A[MESH]|Pulmonary Surfactant-Associated Protein D[MESH]|Pulmonary Surfactant-Associated Proteins[MESH]|Pulmonary Surfactants/*immunology[MESH]|Receptors, Complement/immunology[MESH] |