Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Sialic acid binding receptors (siglecs) expressed by macrophages Munday J; Floyd H; Crocker PRJ Leukoc Biol 1999[Nov]; 66 (5): 705-11Sialic acids are structurally and topographically well-suited to function as ligands in cellular recognition events. Sialoadhesin (Sn) is a sialic acid binding receptor uniquely expressed by macrophage subsets. It is a member of the immunoglobulin (Ig) superfamily with 17 extracellular domains. Sn is a prototypical member of the siglec family of sialic acid binding proteins, which includes CD22, myelin-associated glycoprotein, CD33, and siglec-5. These membrane proteins are involved in discrete functions in the hemopoietic, immune, and nervous systems. The sialic acid binding region of siglecs is localized within the membrane-distal, amino-terminal domain and in the case of Sn, it has been characterized in atomic detail by X-ray crystallography, nuclear magnetic resonance, and site-directed mutagenesis. Our studies on Sn indicate that this receptor is likely to function as a macrophage accessory molecule in a variety of cell-cell and cell-extracellular matrix interactions. CD33 and siglec-5 are also expressed on macrophage subsets as well as other myeloid cells. However, unlike Sn, the properties of these molecules indicate a predominant role in signaling functions rather than in cell-cell interactions.|*Lectins[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Antigens, CD/*metabolism[MESH]|Antigens, Differentiation, Myelomonocytic/*metabolism[MESH]|Carbohydrate Metabolism[MESH]|Cell Adhesion[MESH]|Cell Adhesion Molecules/*metabolism[MESH]|Humans[MESH]|Macrophages/*metabolism[MESH]|Membrane Glycoproteins/*metabolism[MESH]|Molecular Sequence Data[MESH]|N-Acetylneuraminic Acid/*metabolism[MESH]|Receptors, Cell Surface/metabolism[MESH]|Receptors, Immunologic/*metabolism[MESH]|Sialic Acid Binding Ig-like Lectin 1[MESH] |
