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lüll Wnts as kidney tubule inducing factors Vainio SJ; Itaranta PV; Perasaari JP; Uusitalo MSInt J Dev Biol 1999[]; 43 (5): 419-23Since the discovery that inductive tissue interactions regulate nephrogenesis, one of the aims has been to identify the molecules that mediate this induction. The small size of embryonic tissue has limited the possibilities to identify the inducers biochemically, even though such efforts were directed to study, e.g. neural induction (for a comprehensive review, Saxen and Toivonen, Primary embryonic induction, Academic Press, London, 1962). The rapid progress in molecular biology made it possible to identify genes from minute amounts of tissue and provided techniques to generate recombinant proteins to assay their action in classic experimental systems. This led to the identification of some signals that are involved in primary and secondary inductive interactions during embryogenesis. Here, we will review evidence suggesting that secreted signaling molecules from the Wnt gene family mediate kidney tubule induction.|*Embryonic Induction[MESH]|Animals[MESH]|Kidney Tubules/*embryology/metabolism[MESH]|Mesoderm/metabolism[MESH]|Nephrons/metabolism[MESH]|Proteoglycans/physiology[MESH]|Proto-Oncogene Proteins/*metabolism[MESH]|Signal Transduction/physiology[MESH]|Wnt Proteins[MESH]|Wnt4 Protein[MESH] |