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lüll The oral fluoropyrimidines in cancer chemotherapy Lamont EB; Schilsky RLClin Cancer Res 1999[Sep]; 5 (9): 2289-96A classic example of a rationally developed class of anticancer drugs, the fluoropyrimidines are now the focus of further rational approaches to cancer chemotherapy as they are transformed into oral formulations. Given alone, oral 5-fluorouracil (5-FU) has erratic absorption and nonlinear pharmacokinetics. However, when oral 5-FU is given as a prodrug and/or paired with a dihydropyrimidine dehydrogenase inhibitor, the resultant 5-FU has linear pharmacokinetics that may approximate the less myelosuppressive continuous i.v. infusion schedule of 5-FU administration without the use of infusion catheters and pumps. We review the preclinical and clinical experience of several of the oral fluoropyrimidines.|Administration, Oral[MESH]|Antimetabolites, Antineoplastic/*administration & dosage/pharmacokinetics/pharmacology[MESH]|Antineoplastic Combined Chemotherapy Protocols/therapeutic use[MESH]|Capecitabine[MESH]|Deoxycytidine/administration & dosage/analogs & derivatives/pharmacokinetics/pharmacology[MESH]|Fluorouracil/*administration & dosage/pharmacokinetics/pharmacology[MESH]|Humans[MESH]|Prodrugs/administration & dosage/pharmacokinetics/pharmacology[MESH]|Tegafur/administration & dosage/pharmacokinetics/pharmacology[MESH] |