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lüll Amphicrine tumor Mandoky LPathol Oncol Res 1999[]; 5 (3): 239-44The term amphicrine refers to cells, and tumors, which show both exocrine and endocrine features. Author s aim was to analyse the characteristics of these neoplasms. 40 suspicious cases were reviewed. Mucin-stains (PAS, diastase-PAS, Stains-all, Alcian-blue), immunohistochemistry (antibodies against Neuron-Specific Enolase (NSE), and Chromogranin A (CGA), and electronmicroscopic studies were performed to demonstrate exocrine and/or endocrine features of the tumor cells. By means of these methods, 16 cases turned out to be amphicrine tumors. Among them, there were 4 sinonasal, 1 bronchial, 1 mediastinal, 8 gastrointestinal and 2 suprarenal gland neoplasms. In connection to the subject, a brief review is given of amphicrine tumor, regarding its etiological and pathological aspects. These tumors form a distinct clinicopathological entity and should be separated from both neuroendocrine tumors and adenocarcinomas.|Adenocarcinoma/diagnosis/pathology/ultrastructure[MESH]|Adrenal Gland Neoplasms/diagnosis/pathology/ultrastructure[MESH]|Adult[MESH]|Aged[MESH]|Bronchial Neoplasms/pathology/ultrastructure[MESH]|Carcinoid Tumor/diagnosis/pathology/ultrastructure[MESH]|Female[MESH]|Gastrointestinal Neoplasms/pathology/ultrastructure[MESH]|Humans[MESH]|Kidney Neoplasms/pathology/ultrastructure[MESH]|Male[MESH]|Mediastinal Neoplasms/pathology/ultrastructure[MESH]|Microscopy, Electron[MESH]|Middle Aged[MESH]|Mucins/analysis[MESH]|Neoplasms, Complex and Mixed/*diagnosis/*pathology/ultrastructure[MESH]|Paranasal Sinus Neoplasms/pathology/ultrastructure[MESH] |