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lüll Long-term course and outcome in AIDS patients with cerebral toxoplasmosis Arendt G; von Giesen HJ; Hefter H; Neuen-Jacob E; Roick H; Jablonowski HActa Neurol Scand 1999[Sep]; 100 (3): 178-84OBJECTIVES: We compared clinical long-term course and outcome in all AIDS patients admitted to our outpatient department from January, 1989 to June, 1998 with toxoplasma encephalitis (TE) as first AIDS-defining infection (n= 106) and in 106 patients with Pneumocystis carinii pneumonia (PCP) as first AIDS-defining disease. MATERIAL AND METHODS: The 2 groups were matched with respect to age, sex, risk group, degree of immunodeficiency as measured by CD4 cell counts and duration of HIV-1-positivity. TE was diagnosed radiologically and by response to treatment. RESULTS: Forty-three TE patients surviving the first TE symptoms > 14 months developed dementive symptoms, leucoencephalopathy in imaging procedures and died from dementia. In contrast only 5 patients surviving PCP for an equally long period showed dementive symptoms. CONCLUSION: Cerebral infections like toxoplasma encephalitis (TE) may negatively influence HIV-1-activity so far latent in the brain.|AIDS Dementia Complex/diagnostic imaging/parasitology/*therapy[MESH]|AIDS-Related Opportunistic Infections/drug therapy/parasitology/*therapy[MESH]|Adult[MESH]|Anti-Bacterial Agents/administration & dosage[MESH]|Antiprotozoal Agents/administration & dosage[MESH]|Clindamycin/administration & dosage[MESH]|Female[MESH]|Hospitalization[MESH]|Humans[MESH]|Leukocytosis/cerebrospinal fluid/virology[MESH]|Magnetic Resonance Imaging[MESH]|Male[MESH]|Middle Aged[MESH]|Pneumonia, Pneumocystis/therapy[MESH]|Pyrimethamine/administration & dosage[MESH]|Sulfonamides/administration & dosage[MESH]|Survival Analysis[MESH]|Tomography, X-Ray Computed[MESH]|Toxoplasmosis, Cerebral/drug therapy/mortality/*therapy[MESH]|Treatment Outcome[MESH] |