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lüll Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection Carlier MF; Ducruix A; Pantaloni DChem Biol 1999[Sep]; 6 (9): R235-40The molecular link between the signalling pathway regulating the formation of filopodia and the initiation of local actin polymerization has been elucidated: N-WASP, a close homologue of WASP, which is the product of the gene responsible for the Wiskott-Aldrich syndrome, mediates a direct connection between the small G-protein Cdc42 and the Arp2/3 complex.|*Cytoskeletal Proteins[MESH]|Actin-Related Protein 2[MESH]|Actin-Related Protein 3[MESH]|Actins/genetics/*physiology[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Cell Cycle Proteins/genetics/*physiology[MESH]|GTP-Binding Proteins/genetics/*physiology[MESH]|Humans[MESH]|Molecular Sequence Data[MESH]|Nerve Tissue Proteins/genetics/*physiology[MESH]|Signal Transduction/genetics/*physiology[MESH]|Wiskott-Aldrich Syndrome Protein, Neuronal[MESH]|cdc42 GTP-Binding Protein[MESH] |