Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Relationship of ECL cells and gastric neoplasia Waldum HL; Brenna E; Sandvik AKYale J Biol Med 1998[May]; 71 (3-4): 325-35The enterochromaffin-like (ECL) cell in the oxyntic mucosa has a key role in the regulation of gastric secretion since it synthesizes and releases the histamine regulating the acid secretion from the parietal cell. Gastrin is the main regulator of the ECL cell function and growth. Long-term hypergastrinemia induces ECL cell hyperplasia, and if continued, neoplasia. ECL cell carcinoids occur in man after long-term hypergastrinemia in conditions like pernicious anemia and gastrinoma. There is also accumulating evidence that a proportion of gastric carcinomas of the diffuse type is derived from the ECL cell. Furthermore, the ECL cell may, by producing substances with angiogenic effects (histamine and basic fibroblast growth factor), be particularly prone to develop malignant tumors. Although the general opinion is that gastrin itself has a direct effect on the oxyntic mucosal stem cell, it cannot be excluded that the general trophic effect of gastrin on the oxyntic mucosa is mediated by histamine or other substances from the ECL cell, and that the ECL cell, therefore, could play a role also in the tumorigenesis/carcinogenesis of gastric carcinomas of intestinal type.|Animals[MESH]|Carcinoid Tumor/etiology/*metabolism[MESH]|Carcinoma, Neuroendocrine/etiology[MESH]|Carcinoma/etiology/pathology[MESH]|Cell Division[MESH]|Enterochromaffin-like Cells/*metabolism/*pathology[MESH]|Fibroblast Growth Factor 2/metabolism[MESH]|Gastric Mucosa/metabolism[MESH]|Gastrins/metabolism[MESH]|Histamine/metabolism[MESH]|Humans[MESH]|Intestinal Neoplasms/etiology/pathology[MESH]|Stomach Neoplasms/etiology/*metabolism/pathology[MESH] |