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Cell death induced by the Fas/Fas ligand pathway and its role in pathology Waring P; Mullbacher AImmunol Cell Biol 1999[Aug]; 77 (4): 312-7Engagement of the cell death surface receptor Fas by Fas ligand (FasL) results in apoptotic cell death, mediated by caspase activation. Cell death mediated via Fas/FasL interaction is important for homeostasis of cells in the immune system and for maintaining immune-privileged sites in the body. Killing via the Fas/FasL pathway also constitutes an important pathway of killing for cytotoxic T cells. Fas ligand is induced in activated T cells, resulting in activation-induced cell death by the Fas/FasL pathway. Recently it has been shown that the Fas receptor can also be up-regulated following a lesion to the cell, particularly that induced by DNA-damaging agents. This can then result in killing of the cell by a Fas/FasL-dependent pathway. Up-regulation of Fas receptor following DNA damage appears to be p53 dependent.|Animals[MESH]|Apoptosis/*immunology/physiology[MESH]|DNA Damage[MESH]|Fas Ligand Protein[MESH]|Humans[MESH]|Ligands[MESH]|Lymphocyte Activation[MESH]|Membrane Glycoproteins/*physiology[MESH]|T-Lymphocytes, Cytotoxic/immunology[MESH]|T-Lymphocytes/cytology/immunology[MESH]|Tumor Suppressor Protein p53/genetics/physiology[MESH]|Up-Regulation[MESH]|fas Receptor/*physiology[MESH] |
